Temporal Course of Regional Brain Activation Associated with Phonological Decoding

Abstract

Spatiotemporal maps of brain activity were obtained from nine normal volunteers engaged in a pseudoword rhyme-matching task using Magnetic Source Imaging. Following bilateral occipital activity there was a clear temporal progression of activity in the left hemisphere beginning with basal temporal areas followed closely by activity in the angular gyrus and inferior frontal lobe. Medial temporal and posterior superior temporal lobe became active last. There was a strong interhemispheric asymmetry in activity favoring the left hemisphere in all areas. A control, pattern-matching task, with no verbal demands, exhibited a different spatiotemporal pattern of activity. These results agree anatomically with previous studies in other imaging modalities. In addition, the relative timing of activity in basal temporal areas of the left hemisphere supports hypotheses regarding a role for this area in early processing of visually presented verbal material.