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Abstract
We performed this study to determine whether positron emission tomography (PET) would play a useful role in the investigation of cortical visual impairment (CVI). Eight children with CVI and 12 normal volunteers were examined using F-18 fluorodeoxyglucose PET. PET images were spatially transformed on standard templates and normalized with global counts. By using statistical parametric mapping 96 software, PET images of the CVI patients were compared with those of the normal group to display pixels with significantly decreased metabolism (p<0.05). The number of pixels with decreased metabolism in Brodmann’s area (BA) 17 and BAs 18/19 were counted for analysis. All CVI children showed reduced glucose metabolism in BA 17 as well as BAs 18/19 when compared with the normal group. The extent of the areas with decreased glucose metabolism in the occipital lobe ranged widely: from 14% to 65%. These results show that PET may be helpful in the evaluation of children with CVI.