The role of cytokines in corneal immunopathology

Paulo F. Torres Cornea and Immunopathology Unit, Department of Ophthalmology, Hospital Geral de Santo Antonio, Porto; Department of Immunology, Pathobiology and Epidemiology, Institute for Animal Science and Health, Lelystad,

Aize Kijlstra Department of Pathology and Molecular Immunology, Instituto de Ciencias Biomedicas Abel Salazar, University of Porto, Porto, Portugal; Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Abstract

Cytokines play an important role in the pathogenesis of various corneal diseases and during corneal graft rejection. Furthermore, cytokines may also play a role in the maintenance of the integrity of the normal cornea. This review focuses on the effects of several cytokines in corneal immunopathology, including the type of the corneal immune response, angiogenesis, chemotaxis, apoptosis, wound healing, corneal disease, and transplantation. It may provide clues for the future treatment of corneal disease and corneal transplantation rejection.

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The role of cytokines in corneal immunopathology

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The role of cytokines in corneal immunopathology

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