Persealide: A Novel, Biologically Active Component from the Bark of Persea americana (Lauraceae)

Qing Ye Department of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, IN 47907, USA

Zhe-ming Gu Department of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, IN 47907, USA

Lu Zeng Department of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, IN 47907, USA

Geng-xian Zhao Department of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, IN 47907, USA

Ching-jer Chang Department of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, IN 47907, USA

Jerry L McLaughlin Department of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, IN 47907, USA

Soelaksono Sastrodihardjo Department of Education and Culture, Center of Interuniversities, Biology Division, Bandung Institute of Technology, 10 Ganesha St., Bandung 40132, Indonesia

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Abstract

Brine shrimp lethality-directed fractionation of the 95% EtOH extract of the powdered dried bark of Persea americana Mill. var. americana (Lauraceae) led to the isolation of one new C 20 alkyl-alkene acetonyl methyl ester designated persealide (1). Persealide showed moderate cytotoxicity against three solid tumor cell lines: human lung carcinoma (A-549), human breast carcinoma (MCF-7) and human colon adenocarcinoma (HT-29).

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Persealide: A Novel, Biologically Active Component from the Bark of Persea americana (Lauraceae)

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Persealide: A Novel, Biologically Active Component from the Bark of Persea americana (Lauraceae)

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