Antiinflammatory and Antipyretic Activities of Spartidienedione Isolated from Psila spartioides

C Delporte Departamento de Quimica Farmacologica y Toxicologica, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, P.O. Box 233, Santiago-l, Chile; Departamento de Quimica, Facultad de Ciencias, Universidad de Chile, P.O. Box 653, Santiago, Chile

N Backhouse Departamento de Quimica Farmacologica y Toxicologica, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, P.O. Box 233, Santiago-l, Chile

R Negrete Departamento de Quimica Farmacologica y Toxicologica, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, P.O. Box 233, Santiago-l, Chile

M C Gallardo Departamento de Quimica Farmacologica y Toxicologica, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, P.O. Box 233, Santiago-l, Chile

P Rivera Departamento de Quimica Farmacologica y Toxicologica, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, P.O. Box 233, Santiago-l, Chile

Abstract

The antipyretic and antiinflammatory properties of a new sesquiterpene, spartidienedione, isolated from Psila spartioides (Asteraceae) were evaluated in rabbits and guinea pigs. At the dose of 25 mg/kg, this substance showed antipyretic and antiinflammatory activities. Toxicity in mice was determined at the dose of 5.0 g/kg. A description and results of the in vivo study, along with acute toxicity assays are presented.

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Antiinflammatory and Antipyretic Activities of Spartidienedione Isolated from Psila spartioides

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Antiinflammatory and Antipyretic Activities of Spartidienedione Isolated from Psila spartioides

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