Plant Extracts Antiviral Activity against Herpes simplex Virus Type 1 and African Swine Fever Virus

O Silva CECF-L1, Unidade de Farmacognosia, Faculdade de Farmacia da Universidade de Lisboa, Av. das Forcas Armadas, 1600 Lisboa, Portugal; Laboratorio de Biologia Celular Faculdade de Farmacia da Universidade de Lisboa, Av. das Forcas Armadas, 1600 Lisboa, Portugal

S Barbosa CECF-L1, Unidade de Farmacognosia, Faculdade de Farmacia da Universidade de Lisboa, Av. das Forcas Armadas, 1600 Lisboa, Portugal; Centro de Botanica do Instituto de Investigacao Cientifica Tropical, Lisboa, Portugal

A Diniz CECF-L1, Unidade de Farmacognosia, Faculdade de Farmacia da Universidade de Lisboa, Av. das Forcas Armadas, 1600 Lisboa, Portugal

M L Valdeira CECF-L1, Unidade de Farmacognosia, Faculdade de Farmacia da Universidade de Lisboa, Av. das Forcas Armadas, 1600 Lisboa, Portugal

E Gomes CECF-L1, Unidade de Farmacognosia, Faculdade de Farmacia da Universidade de Lisboa, Av. das Forcas Armadas, 1600 Lisboa, Portugal

Abstract

Twenty-eight extracts prepared from plants used in African traditional medicine and from Rhamnus glandulosa Ait. of the Portuguese flora, were screened in order to assay their antiviral activity against Herpes simplex virus type 1 (HSV-1) and African swine fever virus (ASFV). Twelve of these extracts revealed virucidal activity against HSV-1 whereas only six have the same activity against ASFV. Further studies showed that thirteen of the tested extracts inhibited HSV-1 infection, some of which had a significant activity against this virus such as Senna podocarpa (Guill. & Perr.) Lock, Cassia sieberiana DC., Guiera senegalensis J.F. Gmel., Piliostigma thonningii (Schum.) Milne-Redhead, Rhamnus glandulosa Ait. and Uvaria chamae P. Beauv. Four of the twenty-one tested extracts inhibited ASFV infection.

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Plant Extracts Antiviral Activity against Herpes simplex Virus Type 1 and African Swine Fever Virus

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Plant Extracts Antiviral Activity against Herpes simplex Virus Type 1 and African Swine Fever Virus

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