Screening of Some Marine Organism Extracts for cAMP Phosphodiesterase Inhibition, Cytotoxicity, and Antiviral Activity against HSV-1

M Arisawa Laboratory of Herbal Garden, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan

K Hayashi Department of Virology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan

T Nikaido Department of Pharmacognosy, School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274, Japan

K Koike Laboratory of Herbal Garden, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan

D Fujita Toyama Prefectural Fisheries Research Institute, 364 Takatsuka, Namerikawa, Toyama 936, Japan

N Nunomura Toyama Science Museum, 1-8-31 Nishinakanomachi, Toyama 939, Japan

M Tanaka Department of Experimental Therapeutics, Cancer Research Institute, Kanazawa University,13-1 Takaramachi, Kanazawa 920, Japan

T Sasaki Laboratory of Herbal Garden, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan

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Abstract

Methanol and hot water extracts of 71 samples of 56 kinds of marine products were subjected to inhibitory test for cyclicAMP phosphodiesterase (cAMP PDE), cytotoxic and anti-viral screening tests. Among them, 7 extracts of marine products showed a significant inhibition for cAMP PDE and 5 extracts showed a significant cytotoxicity against KB cells at concentrations under 20 µg/ml. Eight extracts of marine products showed higher therapeutic indexes against herpes simplex virus type 1 (HSV-1).

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Screening of Some Marine Organism Extracts for cAMP Phosphodiesterase Inhibition, Cytotoxicity, and Antiviral Activity against HSV-1

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Screening of Some Marine Organism Extracts for cAMP Phosphodiesterase Inhibition, Cytotoxicity, and Antiviral Activity against HSV-1

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