Pharmacological Activities of Gutenburgia cordifolia

K J Achola Department of Pharmacy, University of Nairobi, College of Health Sciences, P.O. Box 19676, Nairobi, Kenya

J W Mwangi Department of Pharmacy, University of Nairobi, College of Health Sciences, P.O. Box 19676, Nairobi, Kenya

K A Sinei Department of Pharmacy, University of Nairobi, College of Health Sciences, P.O. Box 19676, Nairobi, Kenya

R W Munenge Department of Pharmacy, University of Nairobi, College of Health Sciences, P.O. Box 19676, Nairobi, Kenya

A M Mwaura Department of Pharmacy, University of Nairobi, College of Health Sciences, P.O. Box 19676, Nairobi, Kenya

Abstract

A methanol extract of Gutenburgia cordifolia showed a greater fall in diastolic than systolic blood pressure in anaesthetised rats. The plant extract produced cardiodepressant activity on isolated rabbit heart and caused contraction on isolated rabbit ileum. The contraction was reduced but not abolished with atropine. On isolated guinea pig ileum, the contraction was abolished by atropine, the presence of an acetylcholine-like compound in the plant extract is indicated.

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Pharmacological Activities of Gutenburgia cordifolia

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Pharmacological Activities of Gutenburgia cordifolia

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