Oleanolic Acid, a Bioactive Component of the Leaves of Ocimum Gratissimum (Lamiaceae)

C.J. Njoku Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria; Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907-1333, U.S.A.

Lu Zeng Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria

I.U. Asuzu Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria

N.H. Oberlies Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria

J.L. McLaughlin Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria

Abstract

Bioactivity-guided fractionation of the leaves of Ocimum gratissimum L. (Lamiaceae), using the brine shrimp lethality test, led to the isolation of oleanolic acid. Oleanolic acid showed bioactivity against a panel of six human solid tumor cell lines, the nematode Caenorhabditis elegans and yellow fever mosquito larvae Aedes aegypti. Details of the isolation and bioactivities are described.

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Oleanolic Acid, a Bioactive Component of the Leaves of Ocimum Gratissimum (Lamiaceae)

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Oleanolic Acid, a Bioactive Component of the Leaves of Ocimum Gratissimum (Lamiaceae)

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