Anti-Ulcerogenic Evaluation of the Persian Tooth Brush Tree (Salvadora Persica)

E.M. Galati Pharmaco-Biological Department, School of Pharmacy, University of Messina, Messina, Italy

M.P. Germanò Pharmaco-Biological Department, School of Pharmacy, University of Messina, Messina, Italy

A. Rossitto Pharmaco-Biological Department, School of Pharmacy, University of Messina, Messina, Italy

A. d’Aquino Pharmaco-Biological Department, School of Pharmacy, University of Messina, Messina, Italy

R. Sanogo Pharmaco-Biological Department, School of Pharmacy, University of Messina, Messina, Italy

Abstract

The effect of the lyophilized decoction of Salvadora persica on ulceration induced by ethanol, indomethacin and cold restraint stress was investigated in rats. Pre-treatment tests in rats revealed that the extract possessed significant protective action against ulcers induced by ethanol or stress. The protective effect was not altered by indomethacin, administered as a prostaglandin biosynthesis inhibitor. Salvadora persica shows some increase in gastric mucus with a certain diminution in the ulcer index in cold stress-induced ulcers. However, the drug failed to heal ethanol and indomethacin-induced ulcers.

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Anti-Ulcerogenic Evaluation of the Persian Tooth Brush Tree (Salvadora Persica)

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Anti-Ulcerogenic Evaluation of the Persian Tooth Brush Tree (Salvadora Persica)

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