In Vitro And In Vivo Antitrypanosomal Potential Of Nyctanthes Arbor-Tristis Leaves

Abstract

Antitrypanosomal potential of a crude 50% ethanolic extract of Nyctanthes arbor-tristis leaves was evaluated in vitro and in vivo. The extract exhibited trypanocidal activity at the highest concentration (1000 µg/ml) tested. In vivo studies revealed that the extract exerted antitrypanosomal effects at doses of 300 and 1000 mg/kg, intraperitoneally and significantly (P < 0.05; P < 0.01) prolonged the survival period of the Trypanosoma evansi infected mice. However, as soon as the treatment with the extract was discontinued, the parasitaemia increased and resulted in the death of the experimental animals.