Pharmacological Screening of a Methanol Extract from Mormodica charantia in Rodents

Abstract

A methanol leaf extract of Mormodica charantia was evaluated for analgesic and contractile effects. The extract showed a significant reduction in writhing induced by acetic acid in mice and contractile effects on isolated rat stomach strip preparation, but reversed a dimethytubocurarine block of rat diaphragm muscle preparations, suggesting cholinomimetic and analgesic activities.