Cardenolides and Diterpenes as a Source of and Model for Positive Ionotropic Agents

Abstract

Taking the natural cardenolides as a model for new inotropic agents, pimaranic, cyclohexanic and hydroindenic derivatives have been synthesized and tested. Several of these derivatives are positive inotropics and two of the D3a-unsaturated bis(amidinohydrazono)hydroinenes also are selective Na⁺, K⁺-ATPase inhibitors.

Keywords::

• cardiac glycosides
• analogs synthesis
• ionotropic activity