Abstract
The effect of an infusion of Silybum marianum on some enzymes relevant to liver function was investigated in mice. Methoxsalen was administered in doses of 2.5 and 5.0 mg/kg (i.p.) 4 h prior to decapitation. The infusion of Silybum marianum was administered (p.o.) 24 and 2 h before methoxsalen, while the third dose was given together with methoxsalen. The animals were sacrificed 4 h later. The results showed that the content of glutathione, cytochrome P450 and transaminase in animal tissues suggests the hepatoprotective action of Silybum marianum infusion.