Screening of European Fungi for Antibacterial, Antifungal, Larvicidal, Molluscicidal, Antioxidant and Free-Radical Scavenging Activities and Subsequent Isolation of Bioactive Compounds

Caroline Keller Institut de Pharmacognosie et Phytochimie, Universite de Lausanne, Lausanne-Dorigny, Switzerland; Institut de Botanique, Universite de Neuchatel, Neuchatel, Switzerland

Marc Maillard Institut de Pharmacognosie et Phytochimie, Universite de Lausanne, Lausanne-Dorigny, Switzerland; Institut de Botanique, Universite de Neuchatel, Neuchatel, Switzerland

Jean Keller Institut de Pharmacognosie et Phytochimie, Universite de Lausanne, Lausanne-Dorigny, Switzerland; Institut de Botanique, Universite de Neuchatel, Neuchatel, Switzerland

Kurt Hostettmann Institut de Pharmacognosie et Phytochimie, Universite de Lausanne, Lausanne-Dorigny, Switzerland; Institut de Botanique, Universite de Neuchatel, Neuchatel, Switzerland

Abstract

Crude extracts of 57 species of European fungi have been tested for their bactericidal (Bacillus subtilis, Escherichia coli), fungicidal (Candida albicans, Cladosporium cucumerinum), larvicidal (Aedes aegypti), molluscicidal (Biomphalaria glabrata), antioxidant and free-radical scavenging activities. Connatine and 2(3,4-dihydroxyphenyl)glycine, two compounds with antioxidant and free-radical scavenging properties, were subsequently isolated from the methanolic extracts of Lyophyllum connatum (Tricholomataceae) and Cortinarius hercynicus (Cortinariaceae), respectively. In addition, linoleic acid was shown to be molluscicidal.

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Screening of European Fungi for Antibacterial, Antifungal, Larvicidal, Molluscicidal, Antioxidant and Free-Radical Scavenging Activities and Subsequent Isolation of Bioactive Compounds

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Screening of European Fungi for Antibacterial, Antifungal, Larvicidal, Molluscicidal, Antioxidant and Free-Radical Scavenging Activities and Subsequent Isolation of Bioactive Compounds

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