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Abstract
We have investigated the effects of Polypodium leucotomos extracts on nitric oxide (NO) production in bacterial lypopolysaccharide (LPS)-treated J774 macrophages. Co-administration of P. leucotomos extracts with LPS dose-dependently reduced the production of nitrite. At the concentrations tested, P. leucotomos extracts did not inhibit cellular respiration, so cytotoxicity and/or non-specific depression of cellular respiration did not account for the inhibition of nitrite accumulation seen with P. leucotomos extract. The results obtained provide a mechanism by which P. lecotomos extract exerts its anti-inflammatory activity.