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Proceedings of the Meeting : Liver transplantation in an era of organ-shortage. Leuven, April 28 2000

Living-Related Liver Transplantation in Children at Saint-Luc University Clinics : A Seven Year Experience in 77 Recipients

R. RedingPediatric Liver Transplant Program. Departments of Surgery, Saint-Luc University Clinics, Universite catholique de Louvain, Brussels, Belgium.Correspondence[email protected]

Chr. ChardotPediatric Liver Transplant Program. Departments of Surgery, Saint-Luc University Clinics, Universite catholique de Louvain, Brussels, Belgium.

K. PaulPediatric Liver Transplant Program. Departments of Surgery, Saint-Luc University Clinics, Universite catholique de Louvain, Brussels, Belgium.

F. VeyckemansPediatric Liver Transplant Program. Departments of Anaesthesiology, Saint-Luc University Clinics, Universite catholique de Louvain, Brussels, Belgium.

L. Van ObberghPediatric Liver Transplant Program. Departments of Anaesthesiology, Saint-Luc University Clinics, Universite catholique de Louvain, Brussels, Belgium.

S. Clement De CletyPediatric Liver Transplant Program. Departments of Intensive Care, Saint-Luc University Clinics, Universite catholique de Louvain, Brussels, Belgium.

Th. DetaillePediatric Liver Transplant Program. Departments of Intensive Care, Saint-Luc University Clinics, Universite catholique de Louvain, Brussels, Belgium.

Ph. ClapuytPediatric Liver Transplant Program. Departments of Radiology, Saint-Luc University Clinics, Universite catholique de Louvain, Brussels, Belgium.

Chr. Saint-MartinPediatric Liver Transplant Program. Departments of Radiology, Saint-Luc University Clinics, Universite catholique de Louvain, Brussels, Belgium.

M. JanssenPediatric Liver Transplant Program. Departments of Surgery, Saint-Luc University Clinics, Universite catholique de Louvain, Brussels, Belgium.

J. LerutPediatric Liver Transplant Program. Departments of Surgery, Saint-Luc University Clinics, Universite catholique de Louvain, Brussels, Belgium.

E. SokalPediatric Liver Transplant Program. Departments of Pediatrics, Saint-Luc University Clinics, Universite catholique de Louvain, Brussels, Belgium.

J.-B. OttePediatric Liver Transplant Program. Departments of Surgery, Saint-Luc University Clinics, Universite catholique de Louvain, Brussels, Belgium.

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Abstract

The Brussels series ol living related liver transplantation (LRLT) in 77 children (<15 years) is reviewed. Median (range) recipient age at liver transplantation was 1.1 year (0.4-13.1). The main indication for LT was biliary atresia in 55/77 cases (71%). The living-related donor was one of the parents in 74 instances. Hepatic segments 2-3 (n = 67) or 2-3-4 (n = 10) were implanted orthotopically, with a median (range) graft weight to recipient body weight ratio of 3.17% (0.91-8.08). No severe complications or significant long-term sequelae were encountered in the living donors. One and five year survival rates were 92% and 89% for the patients, and 90% and 86% for the grafts, respectively. The retransplantation rate was 2/77 (2.6%), the indication being chronic rejection in both instances. In conclusion, LRLT is now a validated procedure in the living donors as well as in pediatric recipients with chronic or acute liver diseases. In the current context of organ shortage, it provides a valuable alternative to cadaveric LT.

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Living-Related Liver Transplantation in Children at Saint-Luc University Clinics : A Seven Year Experience in 77 Recipients

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