Hepatocellular Carcinoma Associated with Precocious Puberty and Oral Contraceptives. A Case Report

Abstract

A 36-year-old woman presented with sudden abdominal pain and vomiting. Computed tomography showed a tumour of the right hepatic lobe with possible signs of acute haemorrhage. Her medical history revealed precocious puberty when she was a 5-year-old and the use of oral contraceptives for 18 years. Bisegmentectomy was performed and histological examination revealed hepatocellular carcinoma. The role of male and female sex hormones in the development of hepatic tumours has been well documented but, to our knowledge, association with precocious puberty has not yet been described.

Key Words:

• Hepatocellular carcinoma
• precocious puberty
• oral contraceptive

Additional information

Notes on contributors

B. Mansvelt

B. Mansvelt Centre Hospitalier Jolimont-Lobbes Rue Ferrer, 159 B-7100 Haine Saint-Paul, Belgium Tel.: [phone]. Fax: [phone]. E-mail: [email protected]