Prognostic Factors in Gastric Carcinoma with Peritoneal Dissemination

Abstract

Objective: The prognosis for gastric carcinoma patients with peritoneal dissemination is very poor. We evaluated the survival benefit of resection and intravenous chemotherapy in these patients.

Material and methods: We reviewed the hospital records of 348 gastric carcinoma patients with peritoneal dissemination seen during the period from 1986 to 2000.

Results: Based on the grade of anaplasia, 76 (21.8%) were differentiated and 272 (78.2%) were undifferentiated. In the univariate analyses, the factors influencing the 5-year survival rate were histologic type, resection, and intravenous chemotherapy. Using Cox’s proportional hazard regression model, two factors were independent, statistically significant prognostic parameters: resection (risk ratio, 1.48; 95% confidence interval, 0.90-2.46; p<0.05) and intravenous chemotherapy (risk ratio, 1.68; 95% confidence interval 1.15-2.47; p < 0.01). The 5-year survival rate was higher for patients who had intravenous chemotherapy (3.6%) than for patients who did not (2.4%), and also higher for patients who underwent resection (4.8%) than for patients who did not (0%; p < 0.001).

Conclusion: The results highlight the improved survivorship of gastric carcinoma patients with peritoneal dissemination who had resection and received intravenous chemotherapy, compared with those who did not. Although curative resection cannot be performed in this group of patients, we recommend performing resection and subsequent intravenous chemotherapy.

Key Words:

• Gastric carcinoma
• peritoneal metastases
• chemotherapy

Additional information

Notes on contributors

D.Y. Kim

Dong Yi Kim, M.D., Ph.D. Division of Gastro-enterologic Surgery Department of Surgery Chonnam National University Medical School 8, Hakdong, Dongku, Gwangju, 501-757 Korea Tel.: [phone] Fax :[phone] E-mail: [email protected]