Reduction of Peritoneal Adhesion to Polypropylene Mesh with the Application of Fibrin Glue

Abstract

Purpose: The purpose of our study was to evaluate the possibility of the reduction of peritoneal adhesions to a polypropylene mesh with fibrin glue.

Methods: Forty Wistar rats were assigned to two treatment groups: Group 1) hernioplasty with polypropylene mesh plus fibrin glue sealant, and Group 2) hernioplasty with polypropylene mesh without fibrin glue sealant. The variables evaluated were: presence and density of adhesion, organs or abdominal structures adhered to the polypropylene mesh, inflammatory tissular reaction and cell recount.

Results: Group 1 presented a statistically lower adhesion percentage than Group 2 (40% versus 100%, P = 0.0003). The mean areas of mesh patch surfaces covered with adhesions were statistically different between Groups 1 and 2 (0.67 ± 0.65 cm² versus 1.60 ± 0.51 cm²; P = 0.00001). Twelve rats presented with adhesions in Group 1; eleven were adhesions to the epiploon and one to the colon. In Group 2 there were 16 adhesions to the epiploon, 2 to the colon, 1 to the small intestine and 1 to the stomach. Tissular reaction comparison showed a significant difference (21 ± 4.9 versus 17 ± 4.1; P = 0.006).

Conclusions: Fibrin glue sealant significantly reduced the frequency and severity of intra-abdominal adhesions.

Key Words:

• Fibrin glue
• tissue reactivity score
• epiploon
• peritoneal adhesion

Additional information

Notes on contributors

B. Trujillo-Hernández

Benjamin Trujillo-Hernández, M.D., Ph.D. Calle Gorrión # 14, Colonia Lomas Verdes, CP 28017 Colima, Colima, México Tel.: [phone] Fax: [phone] E-mail: [email protected]