The Science behind Topical Negative Pressure Therapy

Abstract

Topical negative pressure therapy (TNP) is an established part of modern wound healing. With an increasing choice in TNP providers, understanding the differing modes of action, the biochemical and biophysical effects on the wound at a microscopic and macroscopic level, plus the role of the interface dressings, will aid the clinician in planning a clear goal of therapy. This article reviews the scientific evidence for TNP to date and explores each mechanism of action and the implications for wound healing and patient outcomes.

Key words:

• Topical negative pressure therapy
• V.A.C.® Therapy
• matrix metalloproteinase
• cytokines
• microvascular blood flow
• perfusion
• cell strain.

Additional information

Notes on contributors

C. Weston

C. Weston Clinical Marketing Manager Northern Europe KCI Medical Ltd. KCI House Langford Locks Kidlington, Oxford, OX5 1GF E-mail: [email protected]