A Merkel Cell Carcinoma Presenting as a Solitary Lymph Node Metastasis without a Primary Lesion. Report of a Case and Review of the Literature

Abstract

Merkel cell carcinoma is an uncommon, aggressive neuroendocrine tumour of the skin. At presentation regional lymph nodes are involved in approximately one third of the patients. In this report a patient is presented in whom merkel cell carcinoma presented as a solitary lymph node metastasis with an unknown primary skin lesion. The diagnosis of unknown primary merkel cell carcinoma including the use of immunohistochemical markers and treatment options based on data from the literature are discussed.

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Notes on contributors

S. de Zeeuw

S. de zeeuw Department of Surgical Oncology Radboud University Nijmegen Medical Centre PO box 9101 6500 HB, Nijmegen, The Netherlands Tel.: [phone] Fax: [phone] E-mail: [email protected]