Spontaneous Pneumothorax in Children with Osteosarcoma: Report of Three Cases and Review of the Literature

Abstract

Spontaneous pneumothorax is a rare manifestation of primary lung cancer or metastasis. It is estimated that < 1% of all cases of spontaneous pneumothorax are tumor-associated and metastatic osteogenic or soft-tissue sarcomas are associated most commonly with pneumothorax especially in the setting of cytotoxic chemotherapy or radiotherapy. In this article, we report three pediatric cases with osteosarcoma that developed spontaneous pneumothorax during chemotherapy with a review of the literature. Two of them had lung metastasis at the time of the detection of pneumothorax and the remaining patient was found to have a bronchopleural fistula.

SPx is an emergency situation and early diagnosis and management can improve prognosis and quality of life of the patient however the optimal management has yet to be determined.

Key Words:

• Ostesarcoma
• pneumothorax
• chemotherapy
• metastasis

Additional information

Notes on contributors

M. Fayda

M. Fayda, M.D. Department of Radiation Oncology Oncology Institute istanbul university Capa, istanbul, Turkey, 34390 Tel.: [phone] E-mail: [email protected]