Pathophysiology and Management of Post Resection Liver Failure

Abstract

Post resection liver failure (PRLF) is defined by the occurrence of jaundice, coagulopathy and encephalopathy after liver resection. When PRLF is present, it has a high morbidity and mortality. The incidence of PRLF ranges between 0–30%. For having a healthy regeneration of the liver remnant an adequate number of hepatocytes and non-parenchymal cells, a normal functional and regenerative capacity and also a good accommodation of haemodynamic changes without congestion are needed. To avoid the presence of PRLF ongoing parenchymal damage after the liver resection should be avoided. So, ischemia reperfusion injury should be minimalized, infection and sepsis should be treated immediately and small for size syndrome should be avoided.

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Notes on contributors

I. Colle

Prof. dr. Isabelle Colle, M.D., Ph.D. Department of Hepatology and Gastroenterology Ghent University Hospital 1K12-E De Pintelaan 185 9000 Gent, Belgium Tel.: [phone] Fax: [phone] E-mail: [email protected]