Effect of Intraperitoneal Thymoquinone on Postoperative Peritoneal Adhesions

Abstract

Background: To determine the effect of thymoquinone on adhesion formation in a rat caecotomy/suture model.

Materials and Methods : Thirty wistar rats were randomized into three groups: The control group received saline and the thymoquinone group received 10 mg/kg thymoquinone after cecal caecotomy/suture model. In the sham group the abdominal wall was closed without any abrasion to the cecum. On day 15, adhesions were classified, and histopathological samples were taken.

Results : There were no incisional hernias or wound dehiscences. In comparing adhesion scores, a significant difference was found between the thymoquinone and the control groups (p < 0.05). The grade of inflammation for the thymoquinone and the sham groups were significantly lower than that of the control group (p < 0.01 and p < 0.001, respectively). Hydroxyproline levels were significantly lower in the sham and thymoquinone groups compared to the control group (p < 0.05).

Conclusions : Based on the results of this study in a rat peritoneal adhesion model, intraperitoneal administered thymo-quinone has a strong anti-adhesive effect.

Additional information

Notes on contributors

Z. Bozdag

Z. Bozdag, Assist. Prof. Dicle University Faculty of Medicine Department of Surgery 21280 Yenisehir, Diyarbakir, Turkey Tel.: [phone] (4239) E-mail: [email protected]