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Acta Orthopaedica Scandinavica Volume 72, 2001 - Issue 3
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Research Article

Increased interleukin-6 in collected drainage blood after total knee arthroplasty: An association with febrile reactions during retransfusion

Martin Handel 1Section of Orthopaedic Surgery, University Hospital, Tubingen, Germany, Departments of 2Transfusion Medicine, University Hospital, Tubingen, Germany, 3Hospital Infection Control, University Hospital, Tubingen, Germany. Correspondence: Dr. M. Handel, Berggasse 155, DE-72762 Reutlingen, Germany. E-mail [email protected]
,
Jochen Winkler 1Section of Orthopaedic Surgery, University Hospital, Tubingen, Germany, Departments of 2Transfusion Medicine, University Hospital, Tubingen, Germany, 3Hospital Infection Control, University Hospital, Tubingen, Germany. Correspondence: Dr. M. Handel, Berggasse 155, DE-72762 Reutlingen, Germany. E-mail [email protected]
,
Rainer F Hörnlein 1Section of Orthopaedic Surgery, University Hospital, Tubingen, Germany, Departments of 2Transfusion Medicine, University Hospital, Tubingen, Germany, 3Hospital Infection Control, University Hospital, Tubingen, Germany. Correspondence: Dr. M. Handel, Berggasse 155, DE-72762 Reutlingen, Germany. E-mail [email protected]
,
Hinnak Northoff 1Section of Orthopaedic Surgery, University Hospital, Tubingen, Germany, Departments of 2Transfusion Medicine, University Hospital, Tubingen, Germany, 3Hospital Infection Control, University Hospital, Tubingen, Germany. Correspondence: Dr. M. Handel, Berggasse 155, DE-72762 Reutlingen, Germany. E-mail [email protected]
,
Peter Heeg 1Section of Orthopaedic Surgery, University Hospital, Tubingen, Germany, Departments of 2Transfusion Medicine, University Hospital, Tubingen, Germany, 3Hospital Infection Control, University Hospital, Tubingen, Germany. Correspondence: Dr. M. Handel, Berggasse 155, DE-72762 Reutlingen, Germany. E-mail [email protected]
,
Martin Teschner 1Section of Orthopaedic Surgery, University Hospital, Tubingen, Germany, Departments of 2Transfusion Medicine, University Hospital, Tubingen, Germany, 3Hospital Infection Control, University Hospital, Tubingen, Germany. Correspondence: Dr. M. Handel, Berggasse 155, DE-72762 Reutlingen, Germany. E-mail [email protected]
&
Stefan Sell 1Section of Orthopaedic Surgery, University Hospital, Tubingen, Germany, Departments of 2Transfusion Medicine, University Hospital, Tubingen, Germany, 3Hospital Infection Control, University Hospital, Tubingen, Germany. Correspondence: Dr. M. Handel, Berggasse 155, DE-72762 Reutlingen, Germany. E-mail [email protected]
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Pages 270-272 | Published online: 08 Jul 2009
 
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Abstract

We determined interleukin-6 (IL-6) concentrations in collected shed drainage blood intended for retransfusion in a prospective study in 81 patients after total knee replacement. We found large increases in IL-6 levels, averaging 6.5 (SD 3.9) ng/mL, in shed blood collected in the first 6 postoperative hours. 3 patients had febrile reactions after collected blood was retransfused. The IL-6 levels in the drainage blood of these patients were very high (9.6-13.4 ng/mL). In the blood collected after 6 hours, IL-6 concentrations increased to 47 (SD 33) ng/mL (p < 0.001). These results suggest a relation between increased interleukin-6 concentrations in shed drainage blood and the occurrence of febrile reactions after retransfusion of such blood.

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