Expression of 5-HT_1B Receptors in Human Nasal Mucosa

Abstract

5-HT_1B receptors were discovered in human nasal mucosa using immunocytochemistry. Strong immunoreaction was seen around small blood vessels mainly confined to the smooth muscle cell layer. In contrast, no immunoreaction for 5-HT_1D was seen. The possibility of local release in connection with specific target receptors suggests a role for 5-HT in the regulation of vascular tone, glandular secretion and epithelial functions and that 5-HT_1B receptor agonists may be of clinical importance.

• Human Nasal Mucosa Immunocytochemistry Serotonin Receptors