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Abstract
Conclusion: Gastric type H+,K+-ATPase in the vestibular end organs may be of importance for K+ circulation and may also be related to pH regulation in vestibular end organs and endolymphatic sac.
Objective: To analyze the expression of gastric-type H+,K+-ATPase in normal mouse vestibular end organs.
Methods: 8 weeks old CBA/J mice were used in this study. The presence of gastric-type H+,K+-ATPase α and β in the vestibular end organs, viz. utricle, saccule, ampulla, vestibular ganglion, and endolymphatic sac, was investigated using immunohistochemistry.
Results: In the vestibular end organs, H+,K+-ATPase α and β were almost identical. H+,K+-ATPase was expressed in sensory cells, the basolateral surface of dark cells, fibrocytes, in vestibular ganglion cells, and in the upper region of the endolymphatic sac epithelial cells.
Disclosure statement
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
Funding
This study was supported by a Grant-in-Aid for Scientific Research (25462643) provided by the Ministry of Education, Science and Culture, Japan, and also by the Swedish Medical Research Council (Grant No. 17X-7305).