PKCα promotes local advancement via its dual roles in nasopharyngeal carcinoma

Abstract

Conclusion: In patients with nasopharyngeal carcinoma (NPC), PKCα is linked to local advancement and plays dual roles in tumorigenesis. Moreover, positive PKCα is associated with 2-year overall survival of NPC.

Objective: This study seeks to investigate the role of PKCα to identify different sub-types in NPC.

Methods: PKCα expression levels were detected in a collection of NPC samples. CT and MRI scans of the corresponding patients were used to assess adjacent tissue invasion and lymph node metastasis. The correlation of tumour invasion and PKCα levels was evaluated by statistical analysis. The correlation between expression level of PKCα and 2-year overall survival was analysed by the Kaplan-Meier curves. Moreover, a multivariate Cox proportional hazard regression analysis was used to identify the independent prognostic factors for NPC.

Results: PKCα is linked to the invasion of adjacent tissues, especially in the skull base. However, down-regulation of PKCα is a risk factor for regional lymph node metastasis. The 2-year overall survival of the PKCα negative group is better than that of the PKCα positive group (PKCα negative group 100%, PKCα positive group 88.5%, p = 0.034). Based on the multivariate Cox proportional hazard regression analysis, age was identified as a risk factor.

Keywords:

• PKCα
• locally advanced
• skull base
• nasopharyngeal carcinoma (NPC)
• regional lymph node metastasis
• overall survival

Acknowledgements

This work was partly supported by the National Natural Science Foundation of China (81372792).

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Additional information

Funding

This work was partly supported by the National Natural Science Foundation of China (81372792).