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Abstract
Conclusions: There is a high propensity for locoregional and isolated regional failure in stage II patients, even though treated with combined therapy. In stage I patients the risk of isolated regional failure was moderate, at levels below 10%.
Background: The neck treatment of early stages of oral tongue squamous cell carcinoma (OTSCC) are still debatable, considering that previous studies have produced diverting results. The purpose of this study is to report on the outcome of patients with stages I–II, with special respect to regional outcome.
Materials and methods: All patients treated for OTSCC at Karolinska University Hospital between 2008–2014 were included. Patient demographics, intention of treatment, treatment modality, time of follow-up and status at follow-up, recurrence, and place of recurrence were recorded.
Results: Of 230 patients, 149 presented within stages I and II. Of those, 105 were electively treated to the neck. In stage I, the risk of presence of disease in the neck specimen was four out of 63 (6%), whereas 17 out of 41 (41%) were positive in stage II patients. The overall risk of isolated regional failure at any time in stage I patients was six out of 89 and in stage II 25 out of 60.
Chinese abstract
结论 即使用联合疗法进行治疗, II期患者局部和孤立区域性失败的可能性仍然很高。在I期患者中, 孤立区域性失败的风险为中度, 低于10％。
背景 口腔舌苔鳞状细胞癌 (OTSCC) 早期阶段的颈部治疗仍然有争议, 考虑到以前的研究产生了转向结果。本研究的目的是报告I-II期患者的治疗结果, 特别是区域性结果。
材料和方法 2008-2014年期间在Karolinska大学医院接受OTSCC治疗的所有患者。记录了患者人口统计学资料、治疗意图、治疗方式、随访时间和随访状态、复发和复发部位。
结果 230例患者中, 149例处在I期和II期。其中, 105人被选择性地治疗到颈部。在第一阶段, 颈部标本中存在疾病的风险是63例中的4例 (6％) , 而在II期患者中, 41例中的17例 (41％) 为阳性。对于I期患者, 任何时间孤立区域性失败的总体风险是89个中的6个, 对于II期患者, 是60个中的25个。
Disclosure statement
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.