Characteristics of sinonasal fibrous dysplasia: experience from a single department

Abstract

Objectives: We summarized the characteristics of fibrous dysplasia patients in our department to obtain clinical data on this disease.

Methods: We retrospectively reviewed 28 patients who were diagnosed with sinonasal fibrous dysplasia based on pathological examination results from March 2012 to February 2017 in our department.

Results: The 28 patients included 16 females and 12 males, and the median age was 31.5 (range, 7–69) years. The three most common symptoms were nasal obstruction (25%), impaired vision (21%) and headache (18%). Most of the tumors were located in the sphenoid sinus (50%), nasal cavity (39%) or ethmoid sinus (36%). The surgical strategy included an exclusive endoscopic approach (25 cases) and an endoscopic approach combined with sublabial incision (three cases). The median follow-up period was 29 months (range, 3–62 months), and three patients were lost to follow-up. Two of the remaining 25 patients developed recurrence. However, since the second surgery, there has been no recurrence to date.

Conclusions: Our study indicates that the treatment of fibrous dysplasia patients should be tailored according to patient and disease characteristics. The main surgical procedure is the endoscopic approach, and the effect is good. Although the recurrence rate is low, follow-up is necessary.

Chinese abstract

目的：总结我院纤维性发育不良患者的特征, 获得此病临床资料。

方法：回顾性分析2012年3月至2017年2月在我院病理检查结果确诊的28例鼻窦纤维性发育不良患者。

结果：28例患者包括16例女性和12例男性, 中位年龄31.5岁（年龄范围7-69岁）。三个最常见的症状是鼻阻塞（25%）、视力障碍（21%）和头痛（18%）。大多数肿瘤位于蝶窦（50%）、鼻腔（39%）或筛窦（36%）。手术方法包括独家内镜方法（25例）和内镜下手术与子唇切口的综合术（3例）。中位随访期为29个月（范围3-62个月）, 3例失访。其余25例患者中有2例复发。然而, 自从第二次手术以来, 迄今为止还没有复发。

结论：我们的研究表明, 纤维性发育不良患者的治疗应根据患者和疾病特征进行调整。主要手术是内镜手术, 效果好。虽然复发率低, 但随访还是必须的。

Keywords:

• Sinonasal fibrous dysplasia
• endoscopic surgery
• prognosis
• recurrence

Acknowledgements

The authors would like to acknowledge Shanghai Natural Science Foundation and Open Research Fund Program of the Institutes of Brain Science, Fudan University.

Disclosure statement

The authors declare that there is no conflict of interests regarding the publication of this paper.

Additional information

Funding

Natural Science Foundation of Shanghai10.13039/100007219100This work was supported by Natural Science Foundation of Shanghai [16ZR1405100].