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Abstract
Background: Prolonged radiation treatment time (RTT) is associated with worse tumor control. Here we identify and determine the implications of factors that predict treatment prolongation in Veterans Affairs (VA) patients undergoing chemoradiation.
Methods: Chart review from July 2000 to October 2013. 81 patients with advanced stage oropharyngeal cancer treated with chemoradiation.
Results: Twenty-nine patients (35.8%) had RTT prolonged by ≥10 days. Prolongation mainly resulted from acute treatment toxicity (n = 22, 76%). There was no significant difference in RTT for patients treated with concurrent cisplatin versus cetuximab, or in patients treated with or without induction chemotherapy. One-/three-year locoregional control and overall survival rates of 83.4%/76.3% and 83.5%/63.6% for patients without prolonged RTT versus 61.8%/61.8% and 82.8%/73.8% for those with prolongation (p >.05).
Conclusions: Prolonged RTT is a significant predictor of worse locoregional control and predominantly resulted from treatment side effects. More aggressive regimens with induction and concurrent chemotherapy did not predispose to prolonged RTT.
Chinese abstract
背景：延长放射治疗时间（RTT）与肿瘤控制欠佳相关。在这里, 我们鉴别并确定预测接受放化疗的退伍军人（VA）患者的治疗延长的因素的作用。
方法：对2000年7月至2013年10月的图表进行了回顾分析。81例晚期或咽癌患者接受了放化疗治疗。
结果：29例患者（35.8%）的RTT延长了10天或更久。延长主要由急性治疗毒性引起（n = 22, 76%）。同时用顺铂与西妥昔单抗治疗的患者或接受化疗或无诱导化疗的患者之间的RTT差异无统计学意义。非延长RTT患者的一年/三年局部控制和总体生存率分别为83.4%/ 76.3%和83.5%/ 63.6%；而延长治疗的患者为61.8%/ 61.8%, 82.8%/ 73.8%（p > 0.05）。
结论：延长的RTT是局部控制的次等重要预测指标, 主要由治疗副作用导致的。诱导和同时化疗的更激进的方案并不一定需要用延长的RTT。
Disclosure statement
No potential conflict of interest was reported by the authors.