Low 25-hydroxyvitamin D levels in postmenopausal female patients with benign paroxysmal positional vertigo

Abstract

Objective: Several studies have reported the association of benign paroxysmal positional vertigo (BPPV) with vitamin D deficiency. This study aimed to evaluate serum 25-hydroxy vitamin D (25 (OH) D) levels in native Chinese postmenopausal women with de novo idiopathic BPPV and to investigate the possible relationship between the occurrence of BPPV and low 25 (OH) D levels.

Methods: This retrospective study comprised of 85 postmenopausal women with de novo idiopathic BPPV and 80 age-matched healthy controls. All subjects had bone mineral density (BMD) and serum 25 (OH) D levels measurements recorded, and the results were compared.

Results: The prevalence of reduced BMD (T score <−1.0) was significantly higher in female patients with BPPV than in healthy controls (71.8% vs. 51.2%, p = .004). The mean serum 25 (OH) D levels were also significantly lower in female patients with BPPV than in healthy controls (19.1 ± 5.2 vs. 22.5 ± 5.8, p < .001). The regression analyses demonstrated that vitamin D deficiency was associated with BPPV with an odds ratio of 2.1 (95% confidence interval = 1.1–3.1, p = .031).

Conclusion: Our study suggests that low 25 (OH) D may be a risk factor for BPPV in postmenopausal women.

Chinese abstract

目的：一些研究报道了良性阵发性位置性眩晕（BPPV）与维生素D缺乏的相关性。本研究旨在评估患原发性BPPV的绝经后的中国妇女的血清25-羟维生素D（25（OH）D）水平, 探讨BPPV发生与低度25（OH）D的可能关系。

方法：本回顾性研究包括85例患原发性BPPV的绝经后妇女和80例年龄相当的健康对照者。记录所有受试者的骨密度（BMD）和血清25（OH）D水平, 并比较结果。

结果：骨密度下降（T分值<1.0）的患病率在BPPV患者中明显高于健康对照组（71.8%比51.2%, p = .004）。BPPV患者的平均血清25（OH）D水平也显著低于健康对照组（19.1 ± 5.2相对于22.5 ± 5.8, p < 0.001）。回归分析显示维生素D缺乏症与BPPV相关, 比值比为2.1（95%可信区间为 1.1-3.1, p = 0.031）。

结论：我们的研究提示, 25（OH）D水平低可能是绝经后妇女患BPPV的危险因素。

Keywords:

• Occurrence
• osteopenia
• osteoporosis
• 25-hydroxy vitamin D
• benign paroxysmal positional vertigo

Acknowledgements

The authors thank the participants of the study.

Disclosure statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article

Additional information

Funding

This study was supported by the Zhejiang Province Regional Center for Neurology, 2015, and the Huamei Foundation of Ningbo No. 2 Hospital under Grant No. 2017HMKY18.