Abstract
Objective: The aim of this work was to analyze the clinical characteristics and pretreatment peripheral blood cell counts of patients with hypopharyngeal squamous cell carcinoma (HPSCC) and determine their relationship with clinical outcomes.
Methods: One hundred ninety-seven patients were eligible for the study. The relationship between survival and pretreatment peripheral absolute neutrophil count (ANC), absolute lymphocyte count (ALC), absolute monocyte count (AMC), neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR) were analyzed by one-way analysis of variance, t-test, and univariate and multivariate analysis.
Results: The median follow-up time was 30.95 months (range 1–82 months). The 3-year disease-free survival (DFS), cancer-specific survival (CSS), and overall survival (OS) rates for all patients were 40.8, 51.0, and 48.1%, respectively. The ANC, AMC, NLR, and LMR were significantly associated with tumor stage and clinical stage (p < .05). A high NLR (≥2.69) and low LMR (<2.98) were significantly associated with poor DFS, CSS, and OS. The LMR was a significant independent prognostic factor for DFS, CSS, and OS (p = .035, .047, and .045, respectively).
Conclusion: The pretreatment LMR should be considered as an independent prognostic factor for patients with HPSCC.
Chinese abstract
目的:本研究的目的是分析下咽癌鳞状细胞癌(HPSCC)患者的临床特征和治疗前外周血细胞计数, 并确定其与临床结果的关系。
方法:179例患者符合研究条件。通过单因素方差分析、t检验、单因素和多因素分析, 分析存活和治疗前外周绝对嗜中性粒细胞计数(ANC)、绝对淋巴细胞计数(ALC)、绝对单核细胞计数(AMC)、嗜中性粒细胞 - 淋巴细胞比率(NLR)和淋巴细胞 - 单核细胞比率(LMR)之间的关系。
结果:中位随访时间为30.95个月(范围为1-82个月)。所有患者的3年无病生存率(DFS)、癌症特异性生存率(CSS)和总生存率(OS)分 别 为 40.8%、51.0 % 和48.1%。 ANC、AMC、NLR和LMR与肿瘤阶段和临床阶段显著相关(p < 0.05)。高NLR(≥2.69)和低LMR(<2.98)与低DFS、CSS和OS显著相关。 LMR是DFS、CSS和OS的显著独立预后因素(分别为, p = 0 .035、0.047和0.045)。
结论:治疗前的LMR应被视为HPSCC患者的独立预后因素。
Disclosure statement
No potential conflict of interest was reported by the authors.