The correlation of immunologic derangement and juvenile recurrent parotitis: an investigation of the laboratory immunological observation

Abstract

Background: Juvenile recurrent parotitis (JRP) is defined as recurrent parotid inflammation, generally associated with nonobstructive sialectasis of the parotid gland. In addition, the etiology remains unclear, probably immunologically mediated.

Aim: The purposes of the present study were to report the relationship between JRP and immune function from the measurement of the JRP patients’ immunoglobulins and T-lymphocyte subset.

Methods: Immunologic assay from 2014 to 2017 of 100 children diagnosed with JRP at Shanghai Ninth Hospital compared with the 100 normal children by age.

Results: The CD4 level of JRP children aged >6 years was significant lower than the one of JRP preschool children (p < .05), while the IgG level was significant higher than the one of the JRP preschool children (p < .05). In comparison with the normal children, the value of CD8 T cells, immunoglobulin G (IgG), immunoglobulin E (IgE), immunoglobulin A (IgA) and C3 (p < .01) of JRP children was significant higher, while the value of CD4 T cells was lower (p < .01) in spite of age. What is more, the value of CD8 T cells of JRP preschool children was much significant higher than the one of the normal preschool children (p < .01).

Conclusion: The immune function of JRP patients may become disorder: the suppression cellular immune function and inadequate humoral immune expression.

Chinese abstract

背景：青少年复发性腮腺炎（JRP）被定义为复发性腮腺炎症, 通常与腮腺的非阻塞性唾液凝集有关。此外, 该病因尚不清楚, 可能是免疫介导的。

目的：通过对JRP患者免疫球蛋白和T淋巴细胞亚群的测定, 探讨JRP与免疫功能的关系。

方法：对2014年至2017年间在上海市第九医院诊断为JRP的100名儿童进行免疫检测, 并与100名正常儿童进行年龄参数比较。

结果：6岁以上JRP儿童的CD4水平明显低于学龄前JRP儿童（P<.05）, 而他们的IgG水平明显高于学龄前JRP儿童（P<.05）。与正常儿童相比, JRP儿童的CD8 T细胞、免疫球蛋白G（IgG）、免疫球蛋白E（IgE）、免疫球蛋白A（IgA）和C3的值高很多（P<.01）, 而CD4 T细胞的值随年龄增长而降低（P<.01）。此外, 学龄前JRP儿童的CD8 T细胞值明显高于学龄前正常儿童（P<.01）。

结论：JRP患者的免疫功能可能失调：细胞免疫功能抑制, 体液免疫表达不足。

Keywords:

• Juvenile recurrent parotitis
• immunologic derangement
• immune function

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (Grant No. 81671004, 81771089, 81800990), the Natural Science Foundation of Shanghai (Grant No. 16ZR1419000).