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Articles

Role of postoperative adjuvant radiotherapy for locally advanced laryngeal cancer: a meta-analysis

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Pages 172-177 | Received 05 Sep 2018, Accepted 20 Oct 2018, Published online: 08 Feb 2019
 

Abstract

Background: Studies have shown mixed results on the role of postoperative adjuvant radiotherapy (PORT) in surgically managed locally advanced laryngeal cancer.

Objectives: The aim of this study is to review and investigate the role of PORT in patients with locally advanced laryngeal cancer using meta-analysis.

Materials and methods: Relevant studies were searched using PubMed and eligible information has been extracted. Then, meta-analysis of hazard ratio (HR) was performed to evaluate the role of PORT in locally advanced laryngeal cancer.

Results: This meta-analysis included 7 published studies containing 2007 patients. For overall survival (OS), patients of locally advanced laryngeal cancer who were treated with PORT have a combined hazard ratio (HR) of 0.67 with 95%CI (0.56, 0.79), compared to those who were not treated with PORT, which was significantly associated with better survival. PORT was also associated with a better disease-free survival (DFS) and local control rate (LCR) in patients with locally advanced laryngeal cancer. The pooled HR and 95%CI for DFS and LCR were 0.72 (0.53, 0.99) and 0.29 (0.09, 0.99), respectively.

Conclusions and significance: This study suggested that PORT could improve the survival of patients with surgically managed locally advanced laryngeal cancer.

Chinese abstract

背景:关于术后辅助放射治疗(PORT)在局部晚期喉癌手术治疗中的作用的研究显示各种不同的结果。

目的:本研究的目的是通过荟萃分析来回顾和探讨PORT在局部晚期喉癌患者中的作用。

材料与方法:采用PubMed检索相关研究, 提取符合条件的信息。然后, 对危险比(HR)进行荟萃分析, 评价PORT对局部晚期喉癌的作用。

结果:这项荟萃分析包括7项发表的研究, 其中涉及2007名患者。对于总生存率(OS), 与未接受PORT治疗的患者相比, 接受PORT治疗的局部晚期喉癌患者的综合危险比(HR)为0.67, 95%可信区间(0.56, 0.79), 这与更好的生存率显著相关。在局部晚期喉癌患者中, PORT与更好的无病生存率(DFS)和局部控制率(LCR)相关。DFS和LCR的合并HR和95%CI分别为0.72(0.53, 0.99)和0.29(0.09, 0.99)。

结论与意义:本研究提示PORT可提高局部晚期喉癌手术治疗患者的生存率。

Acknowledgement

The study was supported by Grants from the National Science Foundation of China (no. 81703057) and Grants from Medical Science Research of Chongqing Health and Family Planning Commission (no. 2017MSXM005).

Disclosure statement

The authors declare that there is no conflict of interests regarding the publication of this article.

Additional information

Funding

The study was supported by Grants from the National Science Foundation of China [no. 81703057] and Grants from Medical Science Research of Chongqing Health and Family Planning Commission [no. 2017MSXM005].

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