Allergy accelerates the disease progression of chronic rhinosinusitis

Abstract

Background: The role of allergy in the development of chronic rhinosinusitis (CRS) in East Asians is not clear.

Aims/objectives: The aim was to investigate the impact of allergies in the clinical characteristics of chronic rhinosinusitis.

Material and methods: A total of 138 CRS patients who underwent endoscopic sinus surgery were included. A brief history of rhinosinusitis symptoms, blood eosinophil count, blood-specific allergen tests, computed tomography (CT) scan findings, Lund-Mackay (LM) CT scores, and Sino-Nasal Outcome Test (SNOT-22) Questionnaire scores, and sinoscopy findings at 3 and 6 months postoperatively.

Results: The ImmunoCAP test was positive in 71(51%) patients and negative in 67(49%) patients. The mean age of those who received endoscopic sinus surgery was 7-years younger in the allergic group compared with the non-allergic group (p = .008). The peripheral eosinophil count in the allergic group was higher than that of the non-allergic group (p = .008). The LM scores and SNOT-22 scores were not significantly different between the two groups. The recurrence rate of nasal polyps in the allergic group was higher but without statistical significance.

Conclusions and significance: Allergy may accelerate the disease progression of CRS. The presence of the serum-specific IgE was correlated with peripheral eosinophil percentage, especially in the CRSwNP patients.

Chinese abstract

背景：过敏对于东亚人慢性鼻窦炎（CRS）发病的作用尚不清楚。

目的：研究过敏对慢性鼻窦炎临床特征的影响。

材料与方法：本研究包括138例经鼻内镜鼻窦手术的CRS患者。记录了术后3个月和6个月鼻窦炎症状、血嗜酸性粒细胞计数、血液特异性过敏原测试、计算机断层扫描（CT）结果、Lund Mackay（LM）CT评分和鼻窦-鼻腔结果测试（SNOT-22）问卷评分以及窦境检查结果。

结果：免疫印迹测试阳性71例（51%）, 阴性67例（49%）。与非过敏组相比, 过敏组接受鼻内镜手术的患者的平均年龄要年轻7岁（p=.008）。过敏组外周嗜酸细胞计数高于非过敏组（P=.008）。两组间的LM评分和SNOT-22评分没有显著差异。过敏组鼻息肉复发率较高, 但无统计学意义。

结论与意义：过敏可加速CRS的病情进展。血清特定性IgE的存在与外周嗜酸性粒细胞百分比相关, CRSwNP患者尤其如此。

Keywords:

• Allergy
• chronic rhinosinusitis
• eosinophil
• SNOT-22
• Lund-Mackay score

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was financially supported by the Ministry of Science and Technology [MOST 105-2314-B-002-165].