http://orcid.org/0000-0002-9734-1682
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Abstract
Background: We aimed to reduce the morbidity related to treatment and to preserve organ function in patients with hypopharyngeal squamous cell carcinoma (HPSCC) by applying a new surgical treatment protocol based on transoral robotic surgery (TORS).
Aims/objectives: In this study, we analyzed the prognostic factors related to survival to confirm the validity and effectiveness of TORS in patients with advanced-stage HPSCC.
Methods: We retrospectively analyzed the data of 44 HPSCC patients who had undergone TORS-based therapy.
Results: In univariate analysis, only the surgical marginal status showed a statistically significant correlation with the survival of the patients (p = .009). In multivariate analysis, surgical margin status was the only statistically significant prognostic factor related to survival (p = .008). Forty-one patients (93.2%) recovered speech function sufficiently to perform daily conversation without artificial aids. Forty-one patients (93.2%) were able to ingest food orally.
Conclusions: In the treatment of advanced hypopharyngeal cancer, TORS-based therapy helped the surgeon obtain a clear surgical margin in patients with HPSCC, and it showed superior oncologic and functional outcomes compared to the existing treatment methods.
背景：我们试图应用经口机器人手术（TORS）的新手术治疗方案来降低与治疗下咽鳞状细胞癌（HPSCC）患者并保持其器官功能相关的发病率。
目的：在本研究中, 我们分析了与生存相关的预后因素, 以确证TORS对于晚期HPSCC患者的合理性和有效性。
方法：我们回顾性分析了44例接受过TORS治疗的HPSCC患者的资料。
结果：在单变量分析中, 只有手术切缘状态显示出与患者生存率在统计学上的显著相关性（p = .009）。在多变量分析中, 手术切缘状态是与生存相关的唯一具有统计学意义的预后因素（p = .008）。 41名患者（93.2％）充分恢复了语言功能, 可以在没有人工辅助的情况下进行日常对话。 41名患者（93.2％）能够口服进食。
结论：在晚期下咽癌的治疗中, 基于TORS的治疗有助于外科医生为患者获得明确的手术切缘。与现有治疗方法相比, 它显示出优越的肿瘤学和功能性结果。
Disclosure statement
No potential conflict of interest was reported by the authors.