![Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5944/TOC-Subject-Sample-2021-Medicine-Dentistry-Nursing-Allied-Health.jpg"})
Abstract
Background: Acellular dermal allograft (AlloDerm) and cartilage perichondrium are two common materials used for repair of tympanic membrane perforations (TMPs). To date, comparative evaluations of their efficacy have rarely been reported.
Aim/objectives: To compare anatomical and audiological outcomes between AlloDerm and cartilage perichondrium in type I tympanoplasty.
Methods: A total of 61 patients of TMP were studied. In total, 27 patients (Group 1) underwent AlloDerm myringoplasty, and the remaining 34 patients (Group 2) underwent perichondrium myringoplasty. Operating time, closure rate and hearing gain were compared between Groups 1 and 2.
Results: Successful closure rates at 6-month follow-up were 88.9% (Group 1) and 82.4% (group 2). The average improvement of air-bone gap (ABG) was 13.5 ± 11.8 dB for Group 1 and 13.1 ± 13.1 dB for Group 2. The difference in between preoperative and 6 months postoperative ABG values was statistically significant (p < .001).
Conclusions and significance: Success rates and improvement of hearing level were similar for the AlloDerm (Group 1) and the cartilage perichondrium (Group 2) groups. However, AlloDerm requires shorter operative time and avoids the incisions in the harvest of allografts. Our results suggest that AlloDerm can be recommended as an attractive alternative to cartilage grafts.
Chinese abstract
背景：脱细胞异体真皮（异体真皮）和软骨膜是修复鼓膜穿孔（TMPs）的常用材料。迄今为止, 对其疗效的比较性评价很少有报道。
目的：比较I型鼓室成形术中异体真皮和软骨膜的解剖和听力学结果。
方法：对61例TMP患者进行研究。共有27例患者（第1组）接受了异体真皮鼓膜成形术, 其余34例患者（第2组）接受了软骨膜鼓膜成形术。比较1组和2组的手术时间、闭合率和听力改善。
结果：6个月随访时成功闭合率为88.9%（第1组）和82.4%（第2组）。1组气骨间隙（ABG）平均改善13.5±11.8dB, 2组为13.1±13.1dB。术前和术后6个月的ABG值差异有统计学意义（P<0.001）。
结论和意义：异体真皮（1组）和软骨膜（2组）组的成功率和听力改善率相似。然而, 异体真皮需要的手术时间更短, 避免了获取异体移植真皮的切口。我们的研究结果表明, 异体真皮可以作为软骨移植的一种有吸引力的替代方式。
Disclosure statement
The authors report no conflict of interest.
Figure 1. Changes of tympanic membrane before and after operation. (A,B) Pre- and post-operative otoendoscopic images of AlloDerm group. (C,D) Pre- and post-operative otoendoscopic images of cartilage perichondrium group. At 6 months after the operation, the tympanic membrane healed completely, without otorrhea, tympanic membrane sclerosis or other complications.
