The characteristics of vHIT gain and PR score in peripheral vestibular disorders

Abstract

Background

Clinical application of vHIT is limited due to a lack of interpretation of vHIT gain and saccades.

Objectives

This research focuses on comparing common vertigo diseases on vHIT gain and saccade divergence(PR score).

Material and Methods

We retrospectively reviewed 165 patients who have one definite diagnosis, good data quality, and can be read by MATLAB software. All patients were grouped into unilateral vestibular dysfunction (UVD), Meniere's disease (MD), vestibular migraine (VM), Ramsay Hunt Syndrome (RHS), bilateral vestibular hypofunction (BVH), benign paroxysmal positional vertigo (BPPV), and acoustic neuroma (AN). PR score was calculated by an open-source software HitCal.

Results

The saccade detection rate is higher than the abnormal vHIT gain on UVD, MD, VM, RHS, BVH and BPPV. PR score combined with vHIT gain could separate the affected side in UVD and RHS. In the MD group, both vHIT gain and PR score have inconspicuous performance. We also found that different compensation levels and hearing loss status affect results.

Conclusions and Significance

vHIT gain combined with PR score enables a proper distinction among common vertigo diseases. PR score is more sensitive than the gain value on evaluating the physiological situation, vestibular compensation and disease progression.

Chinese abstract

背景：由于缺乏对vHIT增益和扫视的解释, vHIT的临床应用是有限的。

目的：本研究的重点是比较常见眩晕病在vHIT增益和扫视差异方面的作用（PR评分）。

资料和方法：我们回顾性分析了165例诊断明确的患者, 数据质量好, 并且可以通过MATLAB软件读取。所有患者分为单侧前庭功能障碍（UVD）、美尼尔氏病（MD）、前庭偏头痛（VM）、Ramsay Hunt综合征（RHS）、双侧前庭功能减退（BVH）、良性阵发性位置性眩晕（BPPV）和听神经瘤（AN）。 PR评分是由开源软件HitCal计算的。

结果：对于UVD、MD、VM、RHS、BVH和BPPV的扫视检测率高于异常vHIT增益。 PR评分与vHIT增益相结合可以将UVD和RHS的患侧分开。在MD组, vHIT增益和PR评分均无明显表现。我们还发现不同补偿水平和听力损失状态会影响结果。

结论和意义：vHIT增益与PR评分相结合, 可以正确区分常见眩晕病。在评估生理状况、前庭补偿和疾病进展方面, PR评分比增益值更为敏感。

Keywords:

• PR score
• vHIT
• Unilateral vestibular dysfunction
• Meniere’s disease

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by grants from the Key International (Regional) Joint Research Program of National Natural Science Foundation of China [grant number NSFC#81820108009] and National Key research and development project of China [grant number 2020YFC20052003].