Comorbidity of cerebellopontine angle meningioma with other primary neoplasms

Abstract

Background

Meningioma is known to be accompanied by other primary neoplasms, yet has been evaluated less than these.

Objective

This study investigated comorbidity of cerebellopontine angle (CPA) meningioma with other primary neoplasms.

Methods

Overall 1,085 meningioma cases including 16 meningiomas at the CPA were enrolled for investigating the presence of other primary neoplasms. Another 16 age-, sex-, and size-matched CPA schwannoma were also included for comparison.

Results

Of a data-base cohort study of overall 1085 meningioma cases, 165 cases (15%) were associated with other primary neoplasms. In contrast, 8 (50%) of 16 CPA meningioma and one (8%) of 16 CPA schwannoma showed other primary neoplasms. Except for one patient who had oral cancer prior to the diagnosis of CPA meningioma by 4 years, the interval from diagnosis of CPA meningioma to that of other primary neoplasm ranged 0–6 (mean, 3.1 ± 2.5) years.

Conclusion

Prevalence of comorbidity with other primary neoplasms is significantly higher in CPA meningioma (50%) than overall meningioma (15%) and CPA schwannoma (8%). In addition to follow-up MR imaging to visualize both residual tumor and regional brain environment after treatment of CPA meningioma, long-term systemic screening for other primary neoplasm is also mandatory.

Chinese abstract

背景：脑膜瘤已知伴有其它原发性肿瘤, 但是对此所做的评价还不够。

目的：本研究调查了小脑桥脑角（CPA）脑膜瘤与其它原发性肿瘤并发的合并症。

方法：招募了总共1085例脑膜瘤病例, 其中包括16例CPA脑膜瘤, 调查其它原发性肿瘤的存在。另外16个年龄、性别和大小匹配的CPA肉瘤也包括在内以进行比较。

结果：在一项针对1085例脑膜瘤病例的数据库队列研究中, 有165例（15％）与其它原发性肿瘤有关。相反, 16例CPA脑膜瘤中有8例（50％）, 16例CPA神经鞘瘤中有1例（8％）显示其它原发性肿瘤。除一名患者从患口腔癌到CPA脑膜瘤的诊断有4年间隔, 从CPA脑膜瘤的诊断到其它原发性肿瘤的诊断时间范围为0-6年（平均3.1±2.5年）。

结论：CPA脑膜瘤合并其它原发性肿瘤的患病率（50％）明显高于总体脑膜瘤（15％）和CPA神经鞘瘤（8％）。在CPA脑膜瘤治疗之后, 除了进行后续MR成像以观察残留的肿瘤和局部脑环境, 对其它原发性肿瘤进行长期全身筛查也是强制性的。

Keywords:

• Cerebellopontine angle
• schwannoma
• meningioma
• comorbidity

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This study was funded by National Science Council (Taiwan) (Grant No. MOST 108-2314-B002-178).