KTP laser alone or combined with bleomycin for pharyngolaryngeal hemangioma: a lesion grade-based determination of prognosis

Abstract

Background

No standard potassium titanyl phosphate (KTP) laser treatment strategy is available yet for pharyngolaryngeal hemangioma.

Objectives

To explore the therapeutic effect of KTP laser, alone or combined with bleomycin injection, for pharyngolaryngeal hemangioma.

Material and methods

This observational study included patients with pharyngolaryngeal hemangioma treated between May 2016 and November 2021: KTP laser under local anesthesia, KTP laser under general anesthesia, or KTP laser combined with bleomycin injection under general anesthesia.

Results

A total of 60 patients were recruited, including 17, 19, and 24 patients with grade 1, 2, and 3 hemangiomas, respectively. A total of 21 patients underwent KTP laser under local anesthesia, 31 underwent KTP laser under general anesthesia, and 8 underwent KTP laser under general anesthesia combined with bleomycin. The cure rates were 100%, 89.5%, and 20.8% for grade 1, 2, and 3 lesions, respectively. The prognosis was significantly different among the grades of hemangioma (p < .001).

Conclusion

KTP laser treatment might be an effective treatment for adult patients with pharyngolaryngeal hemangioma. The size of the hemangioma might be the major factor influencing the prognosis. The method of anesthesia and whether it was combined with bleomycin injection might not affect the prognosis.

Chinese Abstract

背景：目前还没有可用于咽喉血管瘤的标准磷酸氧钛钾 (KTP) 激光治疗方法。

目的：探讨适用于咽喉血管瘤的单独KTP激光或联合博来霉素注射液的治疗效果。

材料和方法：这项观察性研究包括2016 年 5 月至 2021 年 11 月期间接受治疗的咽喉血管瘤患者：局部麻醉下的 KTP 激光, 全身麻醉下的 KTP 激光, 或全身麻醉下的KTP激光联合博来霉素注射。

结果：共招募 60 例血管瘤患者, 其中 1、2、3 级患者分别为 17、19 和 24 例。 共有 21 例患者在局部麻醉下接受了 KTP 激光, 31例患者全麻下接受KTP激光, 8例患者全麻下接受KTP激光合并博来霉素。 1级、2级和3级病变的治愈率分别为100%、89.5%和20.8%。不同级别的血管瘤的预后存在显著差异 (p < .001)。

结论：KTP激光治疗可能是治疗成人咽喉血管瘤的有效方法。血管瘤的大小可能是影响预后的主要因素。 麻醉方式及是否与博来霉素注射液联用可能不会影响预后。

Keywords:

• Potassium titanyl phosphate laser
• hemangioma
• larynx
• pharynx
• treatment

Disclosure statement

No potential conflict of interest was reported by the author(s).