The effect of local dexamethasone on stapedotomy surgery outcomes in patients with otosclerosis

Abstract

Background

Some studies have shown a positive effect of systemic corticosteroid on hearing results after stapedotomy, but its side effects can limit its routine administration.

Aim

The aim of this study was to investigate the effect of local dexamethasone on the results of stapedotomy surgery.

Material and Methods

Fifty two patients undergone stapedotomy surgery for otosclerosis involved. In the case group after stapedotomy we fulfilled the middle ear with dexamethasone and then the placement of the prosthesis was done. In the control group after stapedotomy we did not use dexamethasone in the middle ear.

Results

Gender, age, nausea, vomiting, postoperative vertigo and nystagmus did not significantly differ between the groups. A significant difference was observed in tinnitus rate between two groups. In the case group ABG decrease was higher and bone conduction thresholds improved at frequencies of 1000, 2000, and 4000 three months after surgery.

Conclusion

Since local dexamethasone had a positive effect on the results of stapedotomy surgery, it can be used instead of systemic corticosteroids to reduce the side effects and increasing surgery’s success rate.

Significance

If local dexamethasone had a positive influence on the results of stapedotomy surgery, it can be used instead of systemic corticosteroids to reduce the side effects and increasing surgery’s success rate.

Chinese abstract

背景

一些研究表明, 全身性皮质类固醇对镫骨切开术后的听力结果有积极作用, 但其副作用会限制其常规给药。

目的

本研究的目的是探讨局部地塞米松对镫骨切开术结果的影响。

材料和方法

52 名因耳硬化症接受镫骨切开术的患者参与了该研究。 病例组, 在镫骨切开术后我们用地塞米松填充中耳, 然后完成假体的放置。 对照组, 在镫骨切开术后我们没有对中耳使用地塞米松。

结果

两组之间, 性别、年龄、恶心、呕吐、术后眩晕和眼球震颤无显著差异。 两组之间的耳鸣发生率存在显著差异。 在病例组中, 手术后三个月在频率为 1000、 2000和4000时, ABG 降低幅度较高, 骨导阈值得以改善。

结论

由于局部地塞米松对镫骨切开术的结果有着积极影响, 它可以代替全身性皮质类固醇来减少副作用并提高手术成功率。

意义

如果局部地塞米松对镫骨切开术的结果有积极影响, 那么它就可以代替全身性皮质类固醇来减少副作用并增加手术成功率。

Keywords:

• Otosclerosis
• stapedotomy
• local corticosteroids

Disclosure statement

No potential conflict of interest was reported by the author(s).

Compliance with ethical standards

Study protocol was in accordance with the latest Declaration of Helsinki for medical research involving human subjects and was approved by the ethics committee of Shahid Sadoughi University of Medical Sciences.

This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all participants of the study.