Abstract
Background
Studies of risk factors for middle ear cholesteatoma surgery using population-based data are lacking.
Objectives
To investigate the risk factors for cholesteatoma surgery in adults based on population data from Korea.
Materials and Methods
For this retrospective study, we used Korean National Health Insurance Service National Sample Cohort data. Patients who were 20 years or older and underwent mastoidectomy from 2006 through 2015 under the diagnostic codes of cholesteatoma were defined as patients with middle ear cholesteatoma surgery. The control group was comprised of the remaining database sample in 2006. Sociodemographic factors in 2006 and histories of medical diseases, allergic diseases, and chronic sinusitis from 2003 through 2005 were compared between cholesteatoma surgery and control groups.
Results
A total of 459 patients underwent cholesteatoma surgery. In multivariate Cox regression analysis, age 40–59 years and residence in metropolitan cities and small- and medium-sized cities and counties were significant risk factors for cholesteatoma surgery whereas allergic rhinitis, asthma, atopic dermatitis, and chronic sinusitis were not significant risk factors for middle ear cholesteatoma surgery.
Conclusions and significance
The present study found no evidence of associations between allergic diseases or chronic sinusitis and cholesteatoma surgery in adults.
Chinese Abstract
背景
缺乏使用基于人群数据的对中耳胆脂瘤手术危险因素的研究。
目的
根据韩国人口数据调查成人胆脂瘤手术的危险因素。
材料和方法
在这项回顾性研究中, 我们使用了韩国国民健康保险服务国家样本队列数据。 2006年至2015年在胆脂瘤诊断代码下接受乳突切除术的20岁或以上的患者被定义为中耳胆脂瘤手术患者。 对照组由2006年剩余的数据库样本组成。比较胆脂瘤手术组和对照组之间的2006年社会人口因素以及2003年至2005年的内科疾病史、过敏性疾病史和慢性鼻窦炎史。
结果
共有459例患者接受了胆脂瘤手术。 多因素Cox回归分析显示, 年龄40 ∼ 59岁、居住在大城市和中小城市以及县城是胆脂瘤手术的显著危险因素, 而过敏性鼻炎、哮喘、特应性皮炎、慢性鼻窦炎不是中耳胆脂瘤手术的显著危险因素。
结论和意义
本研究没有发现成人过敏性疾病或慢性鼻窦炎与胆脂瘤手术之间存在相关性的证据。
Acknowledgments
This study was supported by a National Health Insurance Service Ilsan Hospital grant (NHIMC 2020-CR-075) and a National Research Foundation of Korea grant funded by the Korean government (Ministry of Science and ICT; 2019R1F1A1062649). The study used a National Health Insurance Service dataset made available by the National Health Insurance Service of Korea (NHIS-2021-2-006).
Ethical approval
The Institutional Review Board of the National Health Insurance Service Ilsan Hospital approved this study (NHIMC 2020-09-017). Written informed consent was waived by the Institutional Review Board.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Data availability statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.