Subcutaneous Inflammatory Reaction to a Synthetic Auditory Ossicle (Bioceram^®) in Rats

Abstract

Cellular response and inflammatory reaction to synthetic auditory ossicle (Bioceram^®) made from aluminium oxide are investigated. Local inflammatory effects are important in wound healing and in determining biocompatibility of an implant, necessitating the study of biologic effects of implants, especially inflammation and fibrous capsule formation. Bioceram^® discs were implanted subcutaneously in the interscapular region of rats for various periods of time, ranging from 1 day to 300 days. Histological sections 6