Abstract
The outline of this report has already been published as a short communication concerning muta-aspergillic acid, C11H18N2O3, a new growth inhibitant against hiochi-bacteria. Deoxymuta-aspergilhc acid, C11H13N2O, reduction product of muta-aspergillic acid, was converted to 2,5-diketopiperazine, C11H20N2O2, and this compound was shown to be leucyl-valine anhydride since on hydrolysis, it yielded leucine and valine. These results and physical and chemical data on muta-aspergillic acid led to draw the conclusion that formula (I) or (II) is the most possible structure for this antibiotic.
Abstract
The outline of this report has already been published as a short communication concerning the synthesis of deoxymuta-aspergillic acid and its identification with 2-isobutyl-5-isopropyl-3-hydroxypyrazine. This synthesis establishes the structure of muta-aspergillic acid as formula (I).