74
Views
0
CrossRef citations to date
0
Altmetric
Original Articles

Studies on Growth Inhibition of Hiochi-bacteria, Specific Saprophytes of Sake

Part VII. Structure of Muta-aspergillic Acid (1)
Part VIII. Structure of Muta-aspergillic Acid (2)

Pages 658-670 | Received 27 Apr 1961, Published online: 09 Sep 2014
 

Abstract

The outline of this report has already been published as a short communication concerning muta-aspergillic acid, C11H18N2O3, a new growth inhibitant against hiochi-bacteria. Deoxymuta-aspergilhc acid, C11H13N2O, reduction product of muta-aspergillic acid, was converted to 2,5-diketopiperazine, C11H20N2O2, and this compound was shown to be leucyl-valine anhydride since on hydrolysis, it yielded leucine and valine. These results and physical and chemical data on muta-aspergillic acid led to draw the conclusion that formula (I) or (II) is the most possible structure for this antibiotic.

Abstract

The outline of this report has already been published as a short communication concerning the synthesis of deoxymuta-aspergillic acid and its identification with 2-isobutyl-5-isopropyl-3-hydroxypyrazine. This synthesis establishes the structure of muta-aspergillic acid as formula (I).

View correction statement:
Errata

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.