Oxidative Phosphorylation and the Response to an Osmotic Treatment of Liver Mitochondria of Rats Fed an Amino Acid Imbalanced Diet

Abstract

Fatty livers were produced by feeding rats an amino acid imbalanced diet containing 8% of casein supplemented with 0.3% of DL-methionine, and the oxidative phosphorylation of liver mitochondria and homogenates was examined. In contrast to choline deficiency, the mitochondria and the homogenates of fatty liver resulting from such an amino acid imbalance showed almost normal P:O ratio. However, the response to an osmotic treatment of liver mitochondria of rats fed the amino acid imbalanced diet was different from that of normal rats.