Resolution of N-Acyl Amino Acids with Optically Active Neutral Amino Acid Amides

Abstract

A convenient method of chemical resolution of DL-N-acyl amino acids was described. The resolution by using salt of N-acyl derivatives with a certain simple base, especially L-leucin-amide, was discussed. A new agent, L-leucinamide, readily gave L-alanine, L-valine, L-leucine, L-phenylalanine, L-tryptophan and L-methionine from the corresponding DL-N-acyl derivatives. Resolution done with L-tyrosinamide and L-phenylaninamide gave products lower in yield and purity than those resolved with L-leucinamide as resolving agent.