Effect on Liver and Serum Lipids in Rats of Dietary Additions of Fibers and Ionexchangers to a Histidine-excess Diet

Abstract

Feeding a histidine-excess diet caused growth retardation, hepatomegaly, decreased lipid content in the liver and hypotriglyceridemia within 3 days. Hypercholesterolemia was observed after feeding a histidine-excess diet for 6 days. Studies were done to discover whether some dietary fibers and ionexchangers could prevent the hypercholesterolemia induced by feeding a histidine-excess diet for 6 days. Of the dietary fibers and ionexchangers tested, chitosan, konjac mannan, pectin and cholestyramine were effective in preventing hypercholesterolemia. The addition of dietary fibers and ionexchangers to a histidine-excess diet had little or no effect on body weight, liver weight, liver lipids and liver cholesterol.