Specific Inhibition of Bombyx mori Chitinase by Allosamidin

Daizo KogaLaboratory of Biochemistry, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753, Japan

Akira IsogaiLaboratory of Bioorganic Chemistry, Faculty of Agriculture, University of Tokyo, Tokyo 113, Japan

Shohei SakudaLaboratory of Bioorganic Chemistry, Faculty of Agriculture, University of Tokyo, Tokyo 113, Japan

Shogo MatsumotoLaboratory of Bioorganic Chemistry, Faculty of Agriculture, University of Tokyo, Tokyo 113, Japan

Akinori SuzukiLaboratory of Bioorganic Chemistry, Faculty of Agriculture, University of Tokyo, Tokyo 113, Japan

Shigeru KimuraSericultural Experiment Station, Yatabe, Ibaraki 305, Japan

Akio IdeLaboratory of Biochemistry, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753, Japan

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Abstract

Allosamidin, a product of Streptomyces sp. No 1713, inhibited Bombyx mori chitinase specifically in a competitive way with a Ki o f about 0.1 μm. The effect of allosamidin on chitinases from r Streptomyces griseus and Serratia marcescens was weaker, about 1/500 that on B. mori chitinase. Allosamidin did not inhibit yam chitinase, lysozymes of hen egg-white or human urine, or B. mori α-N-acetyl-d-glucosaminidase. The results suggest that allosamidin is a specific inhibitor of the insect chitinase.

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Specific Inhibition of Bombyx mori Chitinase by Allosamidin

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Specific Inhibition of Bombyx mori Chitinase by Allosamidin

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